Molecular Formula | C5H4N2O3 |
Molar Mass | 140.1 |
Density | 1.63±0.1 g/cm3(Predicted) |
Melting Point | 268-270 °C |
Boling Point | 305.2±52.0 °C(Predicted) |
Flash Point | 138.4°C |
Vapor Presure | 0.000191mmHg at 25°C |
Appearance | Purple powder |
Color | White to Light yellow to Light red |
pKa | 2.77±0.20(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.662 |
MDL | MFCD00023267 |
Hazard Symbols | Xi - Irritant |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
HS Code | 29335990 |
Application | as the main formic acid derivative, at the same time, it overcomes the irritation and corrosion of formic acid, and is widely used in feed and aquaculture. As a relatively simple organic acid, 6-hydroxy-4-pyrimidinecarboxylic acid has good acidification and nutritional functions. |
synthetic method | in a 1 L round-bottom flask, add sodium hydroxide solution (10g) to 500 mL of water 55 g of sodium ethyl oxalate (1.05 eq,0.26 mol) and 26 g of formamidine acetate (1 eq,0.25 mol) were added. The reaction mixture was stirred at room temperature for 16 hours. Concentrated HCl was carefully added to the mixture until pH = 1 and a fine solid precipitated, and the reaction mixture was stirred at 0°C for 1 hour. The solid was filtered and then washed with water and ether. The white solid was then left in a vacuum oven heated at 40°C for 20 hours. Tri-saturation reaction in methanol gave 25% yield of the title compound 6-hydroxy-4-pyrimidinecarboxylic acid. Proton nuclear magnetic resonance spectrum (d6 DMSO):12.88(1H,OH),8.24(s,1H),6.83(s,2H). Figure 6-hydroxy-4-pyrimidinecarboxylic acid synthesis |